S100A8/S100A9 and their association with cartilage and bone |
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Authors: | H Zreiqat C R Howlett S Gronthos D Hume C L Geczy |
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Institution: | (1) Biomaterials and Tissue Engineering Research Unit, Biomedical Engineering, School of AMME, The University of Sydney, Sydney, NSW, 2006, Australia;(2) Inflammatory Diseases Research Unit, School of Medical Sciences, University of NSW, Sydney, NSW, 2052, Australia;(3) Mesenchymal Stem Cell Group, Institute of Medical and Veterinary Science/Hanson Institute, Adelaide, SA, 2005, Australia;(4) Institute for Molecular Bioscience, University of Queensland, Queensland, QLD, 4072, Australia |
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Abstract: | S100A8 and S100A9 are calcium-binding proteins expressed in myeloid cells and are markers of numerous inflammatory diseases
in humans. S100A9 has been associated with dystrophic calcification in human atherosclerosis. Here we demonstrate S100A8 and
S100A9 expression in murine and human bone and cartilage cells. Only S100A8 was seen in preosteogenic cells whereas osteoblasts
had variable, but generally weak expression of both proteins. In keeping with their reported high-mRNA expression, S100A8
and S100A9 were prominent in osteoclasts. S100A8 was expressed in alkaline phosphatase-positive hypertrophic chondrocytes,
but not in proliferating chondrocytes within the growth plate where the cartilaginous matrix was calcifying. S100A9 was only
evident in the invading vascular osteogenic tissue penetrating the degenerating chondrocytic zone adjacent to the primary
spongiosa, where S100A8 was also expressed. Whilst, S100A8 has been shown to be associated with osteoblast differentiation,
both S100A8 and S100A9 may contribute to calcification of the cartilage matrix and its replacement with trabecular bone, and
to regulation of redox in bone resorption. |
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Keywords: | S100A8 S100A9 Osteoblasts Chondrocytes Osteoclasts Cartilage |
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