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Defective recovery of semi-conservative DNA synthesis in xeroderma pigmentosum cells following split-dose ultraviolet irradiation.
Authors:E Moustacchi  U K Ehmann  E C Friedberg
Institution:Laboratory of Experimental Oncology, Department of Pathology, Stanford University, Stanford, CA 94305, U.S.A.
Abstract:In normal human fibroblasts we observe an enhancement of the recovery of the rate of semi-conservative DNA synthesis after split-dose UV-irradiation relative to a single total UV dose. The enhanced recovery is totally absent in both a xeroderma pigmentosum variant line and two xeroderma pigmentosum lines belonging to complementation groups A and C.
Keywords:Reprint request should be addressed to Dr  E  Moustacchi  Institut Curie  Biologie  Bǎtiment 110  Centre Universitaire  Orsay 91405 France
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