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Estimation of intramolecular cyclization activation energies via isothermal gravimetric analysis: A technical note |
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| Authors: | Yung-Chi Lee Ashlesh Sheth Jonathan M. Miller |
| Affiliation: | (1) Pharmaceutical Sciences, Pfizer Global Research and Development, 2800 Plymouth Road, 48105 Ann Arbor, MI;(2) Present address: Wyeth Research, 401 N. Middletown Road, 10965 Pearl River, NY;(3) Present address: Schering-Plough, 556 Morris Avenue, 07901 Summit, NJ |
| Abstract: | Summary and Conclusion Isothermal gravimetric analysis was used to monitor the weight loss of 4 exploratory compounds as an indicator of their solid-state thermal stability. Data obtained from TGA were further processed via a model-free isoconversional method to estimate the activation energy values. These values ranged from 140 to 218 kJ/mol and were inversely related to their corresponding surface areas. Based on their activation energy values, the relative stability of these 4 exploratory compounds can be ranked as C>D>B>A and their formulation development activities can be prioritized. Published: August 4, 2006 |
| Keywords: | isothermal analysis thermogravimetric analysis isoconversional model intramolecular cyclization model-free kinetics |
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