Comparative effects of some hydroxylated vitamin D metabolites on parathyrin secretion by dispersed rat parathyroid cells |
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Authors: | M. Gruson J. Demignon J.Del Pino Montes L. Miravet |
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Affiliation: | Unité INSERM N° 18, 6 rue Guy Patin 75010 Paris, France |
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Abstract: | We have previously discussed the action of 1 α,25-(OH)2D3, (24R) 24,25-(OH)2 D3 and (25S) 25,26-(OH)2D3 on parathyrin secretion by isolated rat parathyroid cells. In this work, we have compared these effects with those obtained with 1 α -OH D3, 25-OH D3 and 1 α -OH D2.In decreasing order, the activities were : 1 α,25-(OH)2D3> 1 α -OH D3 (24R) 24,25-(OH)2D3 > 25-OH D3 > (25S) 25,26(OH)2D3> 1 α -OH D2. The presence of two hydroxyl groups with one hydroxyl group in α position seems to have the higher activity to inhibit the parathyroid secretion. At least, the nature of the side chain conformation also plays a part upon the effect of PTH release. |
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