Asymmetric secretion of principal ovarian venous steroids in the primate luteal phase |
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Authors: | Edward L Marut Gary D Hodgen |
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Institution: | Pregnancy Research Branch National Institute of Child Health and Human Development National Institutes of Health Bethesda, Maryland 20205 UK |
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Abstract: | We have characterized the degree of asymmetry of ovarian steroid secretion in the luteal phase of the menstrual cycle in rhesus and cynomolgus monkeys. Femoral blood levels of FSH, LH, progesterone, estradiol and 17-hydroxyprogesterone were determined. In addition, laparotomies were performed in the early, mid or late luteal phase to facilitate localization of the corpus luteum and collection of ovarian venous blood. We conclude that: 1) the ovary bearing the active corpus luteum contributes virtually all of the progesterone entering peripheral circulation in the luteal phase; 2) the ipsilateral ovary secretes more 17-hydroxyprogesterone than the contralateral one, although both are active in the luteal phase; and 3) the asymmetrical secretion of estradiol was manifest only in the early and mid-luteal phase, with ovarian symmetry being reestablished in the late luteal phase. |
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Keywords: | Reprints: Chief Pregnancy Research Branch Building 18 Room 101 NICHD NIH Bethesda MD 20205 |
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