Identifying potential survival strategies of HIV-1 through virus-host protein interaction networks |
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| Authors: | David van Dijk Gokhan Ertaylan Charles AB Boucher Peter MA Sloot |
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| Affiliation: | (1) Computational Science, University of Amsterdam, Sciencepark 107, 1098 XG Amsterdam, The Netherlands;(2) Department of Virology, Erasmus Medical Center, 's-Gravendijkwal 230, 3015 Rotterdam, CE, The Netherlands |
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| Abstract: | Background The National Institute of Allergy and Infectious Diseases has launched the HIV-1 Human Protein Interaction Database in an effort to catalogue all published interactions between HIV-1 and human proteins. In order to systematically investigate these interactions functionally and dynamically, we have constructed an HIV-1 human protein interaction network. This network was analyzed for important proteins and processes that are specific for the HIV life-cycle. In order to expose viral strategies, network motif analysis was carried out showing reoccurring patterns in virus-host dynamics. |
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