The Wnt/Frizzled GPCR signaling pathway |
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Authors: | V L Katanaev |
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Institution: | Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region 142290, Russia. vladimir.katanaev@uni-konstanz.de |
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Abstract: | G protein-coupled receptors (GPCRs) represent the biggest transmembrane receptor family. The Frizzled group of GPCRs is evolutionarily
conserved and serves to transduce signals from the Wnt-type lipoglycoprotein growth factors. The Wnt/Frizzled signaling cascades
are repeatedly used during animal development and are mostly silent in the adult. Improper activation of these cascades, e.g.
through somatic mutation, underlies cancer development in various tissues. Our research over the past years has identified
the trimeric G proteins as crucial transducers of the Wnt/Frizzled cascades in insect and mammalian cells. The current mini-review
summarizes our findings on the role of G proteins in Wnt/Frizzled signaling, as well as on identification of other signaling
intermediates in this physiologically and pathologically important type of intracellular signal transduction. |
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