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Combinatorial library of indinavir analogues: replacement for the aminoindanol at P2' |
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| Authors: | Raghavan Subharekha Yang Zheng Mosley Ralph T Schleif William A Gabryelski Lori Olsen David B Stahlhut Mark Kuo Lawrence C Emini Emilio A Chapman Kevin T Tata James R |
| Institution: | Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. subha_raghavan@merck.com |
| Abstract: | A 1X22X41 combinatorial library or 902 compounds of indinavir analogues was synthesized on the solid support to identify a replacement for the aminoindanol moiety at P2'. 2,6-Dimethyl-4-hydroxy phenol was discovered to be a good replacement for aminoindanol. |
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