Effect of aryl ring fluorination on the antibacterial properties of C4 aryl-substituted N-methylthio beta-lactams |
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Authors: | Long Timothy E Turos Edward Konaklieva Monika I Blum Allison L Amry Amal Baker Ejae A Suwandi Lita S McCain Melodie D Rahman Miti F Dickey Sonja Lim Daniel V |
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Institution: | Department of Chemistry, 4202 E. Fowler Avenue-SCA400, University of South Florida, Tampa, FL 33620, USA. |
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Abstract: | 4-Aryl-substituted N-thiolated beta-lactams are a new family of antibacterial agents possessing unique structure-activity profiles and a mode of action. Unlike traditional beta-lactam antibiotics, which require highly polar enzyme-binding groups, these lactams bear hydrophobic groups on their side chains. In this study, we examine the effect that increasing hydrophobicity, through fluorine substitution in the C(4) aryl ring, has on the antibacterial properties. |
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