Potential biochemical therapy of glioma cancer |
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| Authors: | Yin Li-Tian Fu Yue-Jun Xu Qiao-Ling Yang Jun Liu Zeng-Li Liang Ai-Hua Fan Xiao-Jun Xu Cheng-Gang |
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| Affiliation: | Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Biotechnology, Shanxi University, Taiyuan 030006, PR China. |
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| Abstract: | Glioma is a highly invasive, rapidly spreading form of brain cancer that is resistant to surgical and medical treatment. The recent progresses made in intracellular and ion channels of glioma cells provide a potential new approach for biochemical therapy of brain tumor. In this paper, we reviewed clinical data on chemotherapy by temozolomide and results from new studies on voltage-gated potassium channels, large-conductance Ca(2+)-activated K(+) channels, volume-activated chloride channels, glioma-specific chloride channel and their modulators. These new findings may represent future directions for brain tumor studies and treatment. |
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| Keywords: | Glioma Temozolomide Potassium channels Chloride channels Chlorotoxin |
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