| 非NMDA受体的细胞内调控及其机制 |
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| 引用本文： | 王婧,伍龙军,徐天乐.非NMDA受体的细胞内调控及其机制[J].生命科学,2002,14(5):257-260. |
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| 作者姓名： | 王婧 伍龙军 徐天乐 |
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| 作者单位： | 中国科学技术大学生命科学学院神经生物学与生物物理学系,合肥,230027 |
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| 基金项目： | 国家“973”项目（G1999054000），国家杰出青年基金（30125015） |
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| 摘 要： | 非NMDA受体是AMPA受体和KA受体的统称，其亚基上的胞内C末端上有很多磷酸化脱磷酸化及胞内蛋白的结合位点，这些作用位点与非NMDA受体的调控密切相关。如PKA，PKC，PKG，CaMKⅡ和PTK等蛋白激酶均可调节受体的活性，另外，胞内的一些骨架蛋白和信号蛋白也可与非NMDA受体结合而影响其功能，本文着重综述非NMDA受全的细胞内调控及其机制。
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| 关 键 词： | 磷酸化 胞内蛋白 非NMDA受体 细胞内调控 机制 |
| 文章编号： | 1004-0374(2002)05-0257-04 |
| 修稿时间： | 2001年9月7日 |
Intracellular modulation and its mechanisms of the non-NMDA receptors |
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| WANG Jing,WU Long-Jun,XU Tian-Le.Intracellular modulation and its mechanisms of the non-NMDA receptors[J].Chinese Bulletin of Life Sciences,2002,14(5):257-260. |
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| Authors: | WANG Jing WU Long-Jun XU Tian-Le |
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| Abstract: | Non-NMDA receptors is a general designation of AMPA receptors and KA receptors. Many phosphorylation and dephosphorylation sites as well as the intracellular proteins-binding sites are existed on the C-terminal of the non-NMDA receptor subunits, which are closely related to the modulation of the non-NMDA receptors. For example, many kinds of protein kinases such as PKA, PKC, PKG, CaMK n and PTK can modulate the activity of the receptors. In addition, some scaffolding proteins and signaling proteins are also able to bind to non-NMDA receptors to influence their functions. This review focuses on the intracellular modulation and its mechanisms of non-NMDA receptors. |
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| Keywords: | non-NMDA receptors phosphorylation intracellular proteins modulation |
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