Deactivation of macrophage oxidative burstin vitro by different strains ofHistoplasma capsulatum |
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Authors: | Teruo Ikeda J Russell Little |
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Institution: | (1) Department of Veterinary Microbiology, Azabu University, 1-17-71 Fuchinobe, 229 Sagamihara, Kanagawa, Japan;(2) Departments of Medicine and Molecular Microbiology, Jewish Hospital at Washington University Medical Center, 216 S. Kingshighway Boulevard, 63110 St. Louis, MO, USA |
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Abstract: | It was previously reported thatHistoplasma capsulatum (Hc) yeast not only failed to stimulate a murine macrophage oxidative burst (OB), but they also blunted or abolished OB stimulation by a subsequent encounter with potent stimuli such as zymosan or phorbol 12-myristate 13-acetate (PMA). The present studies show that macrophage deactivation is proportional to the time of incubation and the dose of Hc yeast that induce the deactivated state. Hc yeast derived from a virulent strain (G217B) are more efficient inducers of macrophage deactivation than similar preparations derived from the avirulent Downs Hc strain. Yeast cells of two other pathogenic fungi,Candida albicans andCryptococcus neoformans are shown to stimulate rather than deactivate a macrophage OB. |
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Keywords: | Histoplasma virulence Macrophage deactivation Oxidative burst Superoxide production Yeast aggregation |
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