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A Simple Survival Model for Combined Action of Two Damaging Agents |
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| Authors: | M. Tanushev E. M. Myasnikova Dr. Sci A. Yu. Yakovlev |
| Affiliation: | Institute of Mathematics, Bulgarian Academy of Science, Sofia, Bulgaria Central Research Institute of Roentgenology and Radiology, Ministry of Health of the USSR, Leningrad, USSR |
| Abstract: | The aim of this study was mathematical formalization of the development of two damage processes in response to the combined action of two different damaging agents. The model allows to obtain the parametric family of distributions for the life-span when the organism's death is due to joint effect of two damage processes. Differing by their probabilistic meaning the notions of a priori (M (t)) and a posteriori (M(y)) conditional mean contributions of each damage process to the final effect of combined injury are introduced. The formulas permitting to compute the M and M values on the basis of survival data parametric analysis are given. |
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