Revised enzyme synthesis rate expression in cybernetic models of bacterial growth |
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Authors: | Turner B G Ramkrishna D |
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Affiliation: | School of Chemical Engineering, Purdue University, West Lafeyette, Indiana 47907. |
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Abstract: | A revised enzyme synthesis rate expression for cybernetic models of bacterial growth is presented. The rate expression, which is comprised of inducible and constitutive contributions, provides for a basal enzyme level that is necessary to predict certain types of commonly observed continuous culture transients. The response of a continuous culture to a step change in feed stream composition is simulated using both the old and new formulations, and the ramifications for the "matching-law" formulation are discussed. |
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