Nucleotide sequences of the genes for two distinct cephalosporin acylases from a Pseudomonas strain. |
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| Authors: | A Matsuda K Toma K Komatsu |
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| Affiliation: | Pharmaceutical Research and Development Department, Asahi Chemical Industry Co., Ltd., Fuji, Japan. |
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| Abstract: | Two genes, acyI and acyII, for distinct cephalosporin acylases from Pseudomonas sp. strain SE83 (A. Matsuda, K. Matsuyama, K. Yamamoto, S. Ichikawa, and K.I. Komatsu, J. Bacteriol. 169:5815-5820, 1987) were sequenced. Each sequence contained a single open reading frame for two nonidentical subunits, predicting a common precursor. Some homologies at the amino acid level were found between the acyII-encoded enzyme, but not the acyI-encoded one, and other related acylases. |
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