Antimicrobial effects of esters and amides of 3-(5-nitro-2-furyl)acrylic acid |
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| Authors: | G. Kellová E. Šturdík L. Štibrányi L. Drobnica J. Augustín |
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| Affiliation: | (1) Department of Technical Microbiology and Biochemistry, Faculty of Chemical Technology, Slovak Technical University, 812 37 Bratislava, Czechoslovakia;(2) Department of Organic Chemistry Faculty of Chemical Technology, Slovak Technical University, 812 37 Bratislava, Czechoslovakia;(3) Present address: Research Institute of Preventive Medicine, 833 01 Bratislava, Czechoslovakia |
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| Abstract: | The effect of 18 newly synthesized esters and amides of 3-(5-nitro-2-furyl)acrylic acid on bacteria (Escherichia coli, Staphylococcus aureus), yeasts (Saccharomyces cerevisiae, Candida albicans), molds (Aspergillus niger, Penicillium cyclopium, Rhizopus oryzae) and algae (Chlorella pyrenoidosa, Euglena gracilis, Scenedesmus obliquus) was investigated. The MIC values revealed antimycotic, antialgal and antibacterial activity of the studied derivates. The antimycotic activity was found to decrease with increasing the length of the alkyl chain of esters and after introduction of amino nitrogen into the furylethylene backbone. The inhibitory effect on growth is caused by blocking bioenergetic processes, glycolysis in particular. |
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