Antibody-dependent enhancement of SIV infection: further characterization and cross reactivity between macaque and sooty mangabey isolates |
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| Authors: | D C Montefiori W E Robinson V M Hirsch A Modliszewski W M Mitchell P R Johnson |
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| Institution: | Department of Pathology, Vanderbilt University, School of Medicine, Nashville, TN. |
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| Abstract: | Plasma from four rhesus macaques (Macaca mulatta), of which two were experimentally infected with the simian immunodeficiency virus (SIV) isolate SIVmac251, one with isolate SIVsmF236, and another with a SIVsmF236 molecular clone, SIVsmH-4, enhanced SIVmac infection of MT-2 cells. In addition to SIV-positive plasma, infection-enhancement required complement, CD4, and CR2. Titers of infection-enhancing antibodies appeared to correlate with disease progression. The MT-2/SIVmac251 system should be useful in future studies of complement-mediated, antibody-dependent enhancement of macaque and sooty mangabey SIV isolates. |
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| Keywords: | Lentiviruses Antibodies Complement Immunodeficiency |
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