A diterpene quinone from the bark of Cryptomeria japonica |
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| Authors: | Kofujita Hisayoshi Ota Michikazu Takahashi Kouetsu Kawai Yasushi Hayashi Yoshiki |
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| Affiliation: | Faculty of Agriculture, Iwate University, Ueda 3-18-8, Morioka 020-8550, Japan. kofujita@iwate-u.ac.jp |
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| Abstract: | A diterpene, cryptoquinone, was isolated from the bark of Cryptomeria japonica, the structure, 7,11,14-trioxoabieta-8,12-diene, was established by spectral analyses and X-ray crystallography. This diterpene quinone showed moderate antifungal activities against Pyricularia orizae and Alternaria alternata, and cytotoxic activity against mouse lymphoid neoplasm (P388) cells with an IC(50) of 0.26 microg/ml. |
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| Keywords: | Cryptomeria japonica Abietane Diterpene Quinone Antifungal activity Cytotoxic activity |
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