| 基质金属蛋白酶与类风湿性关节炎 |
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| 引用本文： | 方欢英,杨术生.基质金属蛋白酶与类风湿性关节炎[J].生命的化学,2020(2):216-221. |
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| 作者姓名： | 方欢英 杨术生 |
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| 作者单位： | 同济大学附属东方医院检验科 |
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| 基金项目： | 上海市浦东新区卫生系统重点学科建设资助项目(PWZxk2017-09)。 |
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| 摘 要： | 类风湿性关节炎是一种慢性炎症性自身免疫性疾病,其特点是软骨和骨骼的不可逆损伤。基质金属蛋白酶参与结缔组织重塑,在关节环境炎症级联中起着重要作用,或可成为类风湿性关节炎治疗的潜在新靶点。本文就其在类风湿性关节炎发生发展和治疗中的研究进展作一综述。
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| 关 键 词： | 基质金属蛋白酶 类风湿关节炎 标志物 |
Matrix metalloproteinases and rheumatoid arthritis |
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| FANG Huanying,YANG Shusheng.Matrix metalloproteinases and rheumatoid arthritis[J].Chemistry of Life,2020(2):216-221. |
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| Authors: | FANG Huanying YANG Shusheng |
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| Institution: | (Department of Clinical Laboratory,East Hospital Affiliated to Tongji University,Shanghai 200123,China) |
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| Abstract: | Rheumatoid arthritis is a chronic inflammatory autoimmune disease of unknown etiology hallmarked by irreversible damage of cartilage and bone. Matrix metalloproteinases involved in connective tissue remodeling play an important role in the inflammatory cascade of the joint environment and might be a new underlying target for rheumatoid arthritis therapy. This paper reviewed the advances in research on matrix metalloproteinases involved in the development and treatment of rheumatoid arthritis. |
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| Keywords: | matrix metalloproteinases rheumatoid arthritis marker |
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