| 双特异性磷酸酶3在肿瘤中的作用 |
| |
| 引用本文： | 宋妮妮,杨澍均,欧阳桂芳.双特异性磷酸酶3在肿瘤中的作用[J].生命的化学,2020,40(4):507-512. |
| |
| 作者姓名： | 宋妮妮 杨澍均 欧阳桂芳 |
| |
| 作者单位： | 宁波大学医学院,宁波315211;宁波市第一医院血液科,宁波315010;宁波大学医学院,宁波315211;宁波市第一医院血液科,宁波315010;宁波大学医学院,宁波315211;宁波市第一医院血液科,宁波315010 |
| |
| 摘 要： | 双特异性磷酸酶3(dual-specificity phosphatase 3,DUSP3)是一种双特异性蛋白酪氨酸磷酸酶,其不仅可使磷酸酪氨酸残基去磷酸化,同时也能使磷酸丝/苏氨酸残基去磷酸化。因此,DUSP3具有多样的底物特异性,除了丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)ERK、JNK和p38底物外,还可以作用于其他信号通路的蛋白质,通过MAPK依赖性或非依赖性机制参与细胞周期调控、细胞增殖、衰老、凋亡、迁移以及血管生成、基因组稳定性等多种生物学反应,与肿瘤的发生发展密切相关,是一个潜在的有价值的治疗靶点。本文就DUSP3的生物学特征及其在肿瘤研究中的进展进行了综述。
|
| 关 键 词： | 双特异性磷酸酶3 丝裂原活化蛋白激酶 肿瘤 |
The role of dual-specificity phosphatase 3 in tumors |
| |
| Institution: | (Medical School of Ningbo University,Ningbo 315211,China;Department of Hematology,Ningbo First Hospital,Ningbo 315010,China) |
| |
| Abstract: | Dual-specificity phosphatase 3(DUSP3)is a member of the dual-specificity protein tyrosine phosphatases that can dephosphorylate both tyrosine and serine/threonine residues.DUSP3 has various substrates.In addition to MAPKs ERK,JNK and p38,DUSP3 can also target proteins involved in other signaling pathways,playing important roles in cell cycle regulation,proliferation,senescence,apoptosis,migration,angiogenesis,genomic stability through MAPK-dependent or MAPK-independent mechanisms.DUSP3 has been closely implicated in the occurrence and development of tumors.Therefore,it is a potentially valuable target for therapy.This review summarized the biological characteristics of DUSP3 and its advances in tumor research. |
| |
| Keywords: | dual-specificity phosphatase 3(DUSP3) MAPK tumor |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
