MG53在运动改善胰岛素抵抗中的作用

胰岛素抵抗(insulin resistance, IR)是多种代谢性疾病的共同病理基础,运动作为改善这一病理过程的重要辅助治疗手段,其干预方式、强度和持续时间等尚未明确。MG53(mitsugumin 53)是一种近年来备受关注的骨骼肌细胞膜修复蛋白,有研究表明其不仅是"效应分子",同时也是重要的信号分子——介导多条信号转导通路发挥广泛的生物学效应。本文通过综述MG53调控胰岛素抵抗发生发展的过程,以及MG53介导运动改善胰岛素抵抗的可能信号转导机制,为运动辅助治疗胰岛素抵抗提供新思路。

Function of MG53 in exercise-improved insulin resistance

Insulin resistance(IR)is the common pathological basis of various metabolic diseases.As an important adjuvant therapy to improve the pathological process,the intervention methods,intensity and duration of exercise have not been clarified.MG53(mitsugumin 53)is a skeletal muscle membrane repair protein that has attracted much attention in recent years.Studies have shown that MG53 is not only an“effector molecule”,but also an important signal molecule-mediating multiple signal transduction pathways to play a wide range of biological effects.This review illustrated the process of MG53 regulating the development of insulin resistance,and the possible signal transduction mechanism of MG53 mediating exercise to improve insulin resistance,so as to provide a new idea for exercise-assisted treatment of insulin resistance.