| 胆管癌诊断的分子生物学标志研究进展 |
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| 引用本文： | 干翼超,李宏.胆管癌诊断的分子生物学标志研究进展[J].生命的化学,2020,40(2):236-242. |
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| 作者姓名： | 干翼超 李宏 |
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| 作者单位： | 宁波大学医学院,宁波315000;宁波市医疗中心李惠利医院,宁波315000 |
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| 基金项目： | 浙江省公益技术应用研究计划项目(2017C35002);宁波市重大民生项目(2013C51009);浙江省医药卫生平台计划项目(2016DTA009、2019ZD046)。 |
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| 摘 要： | 胆管癌(cholangiocarcinoma, CCA)是第二常见的原发性肝脏恶性肿瘤。由于该病症隐匿,早期诊断困难,大多数患者在晚期才被发现且患者预后较差,因此早期诊断成为胆管癌治疗的关键。分子生物学标志可以标记系统、器官、组织、细胞及亚细胞结构及其功能的改变。大量研究表明,某些分子生物学标记物的检测有助于CCA的早期诊断,故本文旨在总结与CCA诊断相关的分子生物学标记物及其研究进展。
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| 关 键 词： | 胆管癌 分子生物学标志 诊断 |
Advances in molecular biomarkers for diagnosis of cholangiocarcinoma |
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| GAN Yichao,LI Hong.Advances in molecular biomarkers for diagnosis of cholangiocarcinoma[J].Chemistry of Life,2020,40(2):236-242. |
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| Authors: | GAN Yichao LI Hong |
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| Institution: | (Medical School of Ningbo University,Ningbo 315400,China;LiHuili Hospital of Ningbo Medical Center,Ningbo 315400,China) |
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| Abstract: | Cholangiocarcinoma(CCA) is the second primary liver malignancy. Due to the hidden state of the disease, early diagnosis is difficult, most patients are only discovered in the late stage with poor prognosis. Early diagnosis is the key for CCA treatment. Molecular biomarkers can mark the changes in the structure and function of systems, organs, tissues, cells and subcells. The detection of certain molecular biological markers is helpful for the early diagnosis of CCA, so this review aims to summarize the research progress of molecular biological markers related to CCA diagnosis. |
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| Keywords: | cholangiocarcinoma biomarkers diagnosis |
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