| 同型半胱氨酸与年龄相关性疾病 |
| |
| 引用本文： | 张越,叶红华. 同型半胱氨酸与年龄相关性疾病[J]. 生命的化学, 2020, 40(4): 561-567 |
| |
| 作者姓名： | 张越 叶红华 |
| |
| 作者单位： | 宁波大学医学院,宁波315000;中国科学院大学宁波华美医院,宁波315000 |
| |
| 基金项目： | 宁波医学科技项目;宁波临床医学品牌学科基金项目;宁波华美科研基金项目 |
| |
| 摘 要： | 同型半胱氨酸是甲硫氨酸循环中重要的中间产物,在体内参与甲基化反应而发挥重要的生理作用。许多因素影响血循环同型半胱氨酸水平。已有研究表明,血浆同型半胱氨酸浓度升高增加多种老年性疾病的发病风险,如心血管疾病、痴呆、骨折等,氧化应激是其目前公认的致病机制之一。本文综述了同型半胱氨酸与心血管疾病、认知功能障碍或痴呆、骨质疏松性骨折的相关性及其致病机制。
|
| 关 键 词： | 同型半胱氨酸 心血管疾病 痴呆 骨折 |
Homocysteine level and age-related diseases |
| |
| ZHANG Yue,YE Honghua. Homocysteine level and age-related diseases[J]. Chemistry of Life, 2020, 40(4): 561-567 |
| |
| Authors: | ZHANG Yue YE Honghua |
| |
| Affiliation: | (Medicine School of Ningbo University,Ningbo 315000,China;University of Chinese Academy of Sciences,Huamei Hospital,Ningbo 315000,China) |
| |
| Abstract: | Homocysteine is an important intermediate product of methionine cycle, playing a key physiological role in many methylation reactions in the body. Many factors have an influence on circulating homocysteine level. A number of studies have found that elevated plasma homocysteine concentration is associated with multiple age-related diseases, such as cardiovascular disease, dementia and fracture. Oxidative stress is one of the most acceptable pathogenesis mechanisms. This review summerized the relationship between homocysteine and cardiovascular disease, cognitive dysfunction or dementia, osteoporosis fracture and its potential pathogenesis. |
| |
| Keywords: | homocysteine cardiovascular disease dementia fracture |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
