pH敏感纳米药物载体在肿瘤治疗中的应用研究

pH敏感的纳米递药系统能有效利用其纳米尺寸以及敏感的连接键响应生物体内外不同的刺激,并通过在肿瘤部位选择性释药、增加药物的蓄积、减少药物在血液循环过程中的渗漏以及减轻毒副作用等方式提高药物生物利用度。根据肿瘤组织内不同的pH值构建多种刺激-响应型纳米载药系统是肿瘤治疗领域的发展趋势。本文综述了pH敏感的纳米药物载体在肿瘤治疗领域的研究与进展,以期为今后相关内容的深入研究提供借鉴。

pH-sensitive nano-drug delivery systems for cancer therapy

The pH-sensitive nano drug delivery system could effectively utilize its nano-size and sensitive linkages to selectively release drugs at tumor tissues in response to different stimuli in vivo and in vitro. It could increase the drug accumulation at the tumor tissues and reduce the drug leakage during the blood circulation, leading to enhanced drug bioavailability and reduced the side effects of drugs. It was a development trend in the field of cancer therapy to construct a variety of pH-sensitive nano drug delivery systems based on different pH values in tumor tissues. This review focused on the research and progress of pH-sensitive nano drug delivery systems for cancer therapy, to provide reference for further research.