Influence of amino acid substitutions in the leader peptide on maturation and secretion of mesentericin Y105 by Leuconostoc mesenteroides |
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| Authors: | Aucher Willy Lacombe Christian Héquet Arnaud Frère Jacques Berjeaud Jean-Marc |
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| Affiliation: | Institut de Biologie Moléculaire et d'Ingénierie Génétique, Equipe de Microbiologie Fondamentale et Appliquée, UMR CNRS 6008, Université de Poitiers, Poitiers, France. |
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| Abstract: | By site-specific mutagenesis, the hydrophobic conserved amino acids and the C-terminal GG doublet of the leader peptide of pre-mesentericin Y105 were demonstrated to be critical for optimal secretion of mesentericin Y105, as well as for the maturation of the pre-bacteriocin by the protease portion of the ABC transporter MesD. |
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