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Solution-Phase, parallel synthesis and pharmacological evaluation of acylguanidine derivatives as potential sodium channel blockers |
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| Authors: | Seetharamaiyer Padmanabhan Ruth C. Lavin Paresh M. Thakker Jinqing Guo Lu Zhang Deke Moore Michael E. Perlman Cassandra Kirk Deborah Daly Kathy J. Burke-Howie Teresa Wolcott Suchitra Chari David Berlove James B. Fischer William F. Holt Graham J. Durant Robert N. McBurney |
| Affiliation: | CeNeS Pharmaceuticals Inc., 333 Providence Highway, Norwood, MA 02062, USA |
| Abstract: | Solution-phase synthesis of various acylguanidine derivatives and the evaluation of a small library of compounds as potential sodium channel blockers are described. |
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