Synthesis of 5-substituted-2,3-dihydro-1,4-benzoxathiins: biological evaluation as melatonin receptors ligands |
| |
| Authors: | Charton Isabelle Suzenet Franck Boutin Jean A Audinot Valérie Delagrange Philippe Bennejean Caroline Renard Pierre Guillaumet Gérald |
| |
| Institution: | Institut de Chimie Organique et Analytique, UMR-CNRS 6005, Université d'Orléans, rue de Chartres, BP 6759, 45067 Orléans Cedex 02, France. |
| |
| Abstract: | The synthesis of benzoxathiins bearing a retroamide function is described from 8-hydroxythiochroman, the key step involving the synthesis of the benzoxathiin ring through a sulfonium salt. These new melatonin analogues were evaluated on human receptors MT1 and MT2 and have a similar affinity to that of melatonin itself. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
