Synthesis and cytotoxic activity against a non-small-cell bronchopulmonary carcinoma line (NSCLC-N6) of benzofuran enantiomeric derivatives |
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| Authors: | Hélesbeux J J Duval O Séraphin D Roussakis C Richomme P |
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| Affiliation: | Laboratoire SONAS, UFR des Sciences Pharmaceutiques et Ingénierie de la Santé, 16, Bd Daviers, 49100 Angers, France. |
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| Abstract: | The synthesis of 2-isopropenyl-2,3-dihydrobenzofuranic enantioisomers is described. Ortho-(2-hydroxy-3-methyl-but-3-enyl)phenol synthons are used as precursors to these structures. In vitro antitumor activity against a non-small-cell bronchopulmonary carcinoma line (NSCLC-N6) of these enantioisomers has been investigated. |
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