Molecular analysis of a gene fromBacteroides fragilis involved in metronidazole resistance inEscherichia coli |
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| Authors: | Gabi U Wehnert Valerie R Abratt David R Woods |
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| Abstract: | The region ofBacteroides fragilis DNA on the recombinant plasmid pMT100 responsible for conferring metronidazole resistance inEscherichia coli strains was characterized. An open reading frame (ORF1) of 195 bp encoded a protein of 64 amino acids with a predicted Mr, of 7.3 kDa. Deletion analysis indicated that ORF1 conferred the metronidazole resistance phenotype and encoded a protein with an apparent Mr of approximately 8–10 kDa. |
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