Type-III effectors: sophisticated bacterial virulence factors |
| |
Authors: | Abe Akio Matsuzawa Takeshi Kuwae Asaomi |
| |
Affiliation: | Laboratory of Bacterial Infection, Kitasato Institute for Life Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan. abe@lisci.kitasato-u.ac.jp |
| |
Abstract: | Bacterial pathogens cause a wide spectrum of diseases in human and other animals. Some virulence factors, which are referred to as effectors, are directly translocated into the host cell via an injection apparatus, i.e., the type-III secretion system. Most effectors mimic host molecules, and translocated effectors are thereby able to perturb or modulate host cell signaling, cytoskeletal rearrangement, vesicular traffic, and autophagy, thus eliciting disease. Effectors are roughly classified among exotoxins, but in most cases, their functions are exerted focally when they are translocated into the host cell. |
| |
Keywords: | Type-III secretion system Effector Rho family Actin Microtubule Vesicular traffic Autophagy Systèmes de sécrétion de type III Effecteur Famille rhô Actine Microtubule Circulation vesiculaire Autophagie |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|