Effect of repeated oral administration of quinalphos to male goat (Capra hircus)

Quinalphos given in daily oral doses of 0.5 mg/kg for 110 days induced severe signs of organophosphorus poisoning in male goats. The inhibition of acetylcholinesterase activity in erythrocyte was highly significant. The activity of liver glutamic; oxaloacetic transaminase, glutamic; pyruvic.transaminase, alkaline phosphatase and protein indicated marked alteration. The haematological changes were however, relatively less significant with the exception of a very low count of red blood cells and white blood cells in the treated animals. Among the vital organs, only liver suggested mild cellular changes due to quinalphos intoxication. There was no significant pathological change in other organs of the treated animals. In animals observed after 15 and 30 days rest, the activity of acetylcholinesterase in red blood cells and haematological picture showed a fairly good recovery. This study suggests that although quinalphos in low concentrations did not produce discernible cellular changes, it induced highly significant enzymatic and haematological changes in the goat.