The novel mechanism of initiation of picornavirus RNA translation |
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Authors: | Richard J Jackson Michael T Howell and Ann Kaminski |
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Institution: | Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, UK |
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Abstract: | The initiation of translation of picornaviral RNAs takes place by an unusual mechanism whereby ribosomes bind directly to an internal site rather than scan the RNA from the 5′-end. This internal entry mechanism requires a 450-nucleotide segment of the picornavirus 5′-untranslated region. The ribosome binds initially to a site at the 3′-end of this segment, and then may scan the RNA to reach the authentic initiation site. This novel mechanism may be of relevance to the translation of some cellular mRNAs. |
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