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Vacuolar-type H(+)-ATPase inhibitory activity of synthetic analogues of the concanamycins: is the hydrogen bond network involving the lactone carbonyl,the hemiacetal hydroxy group,and the C-19 hydroxy group essential for the biological activity of the concanamycins?
引用本文:Yoshimoto Y,Jyojima T,Arita T,Ueda M,Imoto M,Matsumura S,Toshima K. Vacuolar-type H(+)-ATPase inhibitory activity of synthetic analogues of the concanamycins: is the hydrogen bond network involving the lactone carbonyl,the hemiacetal hydroxy group,and the C-19 hydroxy group essential for the biological activity of the concanamycins?[J]. Bioorganic & medicinal chemistry letters, 2002, 12(24): 3525-3528. DOI: 10.1016/S0960-894X(02)00806-5
作者姓名:Yoshimoto Y  Jyojima T  Arita T  Ueda M  Imoto M  Matsumura S  Toshima K
摘    要:

收稿时间:2002-08-29

Vacuolar-type H+-ATPase inhibitory activity of synthetic analogues of the concanamycins: Is the hydrogen bond network involving the lactone carbonyl,the hemiacetal hydroxy group,and the C-19 hydroxy group essential for the biological activity of the concanamycins?
Yoshimoto Yuya,Jyojima Takaaki,Arita Tsuyoshi,Ueda Minoru,Imoto Masaya,Matsumura Shuichi,Toshima Kazunobu. Vacuolar-type H+-ATPase inhibitory activity of synthetic analogues of the concanamycins: Is the hydrogen bond network involving the lactone carbonyl,the hemiacetal hydroxy group,and the C-19 hydroxy group essential for the biological activity of the concanamycins?[J]. Bioorganic & medicinal chemistry letters, 2002, 12(24): 3525-3528. DOI: 10.1016/S0960-894X(02)00806-5
Authors:Yoshimoto Yuya  Jyojima Takaaki  Arita Tsuyoshi  Ueda Minoru  Imoto Masaya  Matsumura Shuichi  Toshima Kazunobu
Affiliation:

a Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan

b Department of Bioscience and Informatics, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan

c Department of Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan

Abstract:Synthetic analogue of the concanamycins, which lacks the hydrogen bond network existing in the concanamycin structure, retains vacuolar-type H+-ATPase (V-ATPase) inhibitory activity and induces apoptosis to cancer cells that overexpressing epidermal growth factor receptors (EGFR).
Keywords:
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