Synthesis and biological evaluation of NAD analogs as human pyridine nucleotide adenylyltransferase inhibitors |
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| Authors: | Franchetti Palmarisa Petrelli R Cappellacci L Pasqualini M Vita P Sorci L Mazzola F Raffaelli N Magni Giulio |
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| Institution: | Dipartimento di Scienze Chimiche, Università di Camerino, Camerino, Italy. palmarisa.franchetti@unicam.it |
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| Abstract: | NAD analogs modified at the ribose adenylyl moiety, named N-2'-MeAD and Na-2'-MeAD, were synthesized as ligands of pyridine nucleotide (NMN/NaMN) adenylyltransferase (NMNAT). Both dinucleotides resulted selective inhibitors against human NMNAT-3 isoenzyme. |
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