Human intronic enhancers control distinct sub-domains of Gli3 expression during mouse CNS and limb development |
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| Authors: | Amir A Abbasi Zissis Paparidis Sajid Malik Fiona Bangs Ansgar Schmidt Sabine Koch Javier Lopez-Rios Karl-Heinz Grzeschik |
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| Affiliation: | 1.Department of Human Genetics,Philipps-Universit?t Marburg,Marburg,Germany;2.National Center for Bioinformatics, Faculty of Biological Sciences,Quaid-i-Azam University,Islamabad,Pakistan;3.Department of Animal Sciences,Quaid-i-Azam University,Islamabad,Pakistan;4.Biology and Biochemistry Department,University of Bath,Bath,UK;5.Department of Pathology,Philipps-Universit?t Marburg,Marburg,Germany;6.DBM Center for Biomedicine,University of Basel Medical School,Basel,Switzerland |
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| Abstract: | Background The zinc-finger transcription factor GLI3 is an important mediator of Sonic hedgehog signaling and crucial for patterning of many aspects of the vertebrate body plan. In vertebrates, the mechanism of SHH signal transduction and its action on target genes by means of activating or repressing forms of GLI3 have been studied most extensively during limb development and the specification of the central nervous system. From these studies it has emerged, that Gli3 expression must be subject to a tight spatiotemporal regulation. However, the genetic mechanisms and the cis-acting elements controlling the expression of Gli3 remained largely unknown. |
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