Antibiotic properties of novel synthetic temporin A analogs and a cecropin A-temporin A hybrid peptide |
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| Authors: | Wade David Flock Jan-Ingmar Edlund Charlotta Löfving-Arvholm Ingegerd Sällberg Matti Bergman Tomas Silveira Angela Unson Cecille Rollins-Smith Louise Silberring Jerzy Richardson Malcom Kuusela Pentti Lankinen Hilkka |
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| Affiliation: | Karolinska Institutet, Department of Microbiology, Pathology, and Immunology, Division of Clinical Virology, F-68, Huddinge University Hospital, S-14186 Huddinge, Sweden. |
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| Abstract: | Temporin A, 18 analogs, and a cecropin A-temporin A hybrid peptide were tested with antibiotic sensitive and resistant bacteria, fungi, human erythrocytes, and in clotting assays. Several peptides were active in these assays, and some analogs (D-TA, W1-TA, and Con-L4,G10) may be useful lead compounds for further antibiotics development. The activity of temporin A was found to be dependent upon several of its structural features, including amino acid composition and sequence, chirality, helicity, and positive charge. |
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