Early- and advanced non-enzymatic glycation in diabetic vascular complications: the search for therapeutics |
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Authors: | Casper G Schalkwijk Toshio Miyata |
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Institution: | (1) Department of Internal Medicine, University Hospital Maastricht, P. Debyelaan 25, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands;(2) United Centers for Advanced Research and Translational Medicine (ART), Tohoku University Graduate School of Medicine, 2-1 Seiryo-Machi, Aoba-ku, Sendai Miyagi, 980-8575, Japan |
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Abstract: | Cardiovascular disease is a common complication of diabetes and the leading cause of death among people with diabetes. Because
of the huge premature morbidity and mortality associated with diabetes, prevention of vascular complications is a key issue.
Although the exact mechanism by which vascular damage occurs in diabetes in not fully understood, numerous studies support
the hypothesis of a causal relationship of non-enzymatic glycation with vascular complications. In this review, data which
point to an important role of Amadori-modified glycated proteins and advanced glycation endproducts in vascular disease are
surveyed. Because of the potential role of early- and advanced non-enzymatic glycation in vascular complications, we also
described recent developments of pharmacological inhibitors that inhibit the formation of these glycated products or the biological
consequences of glycation and thereby retard the development of vascular complications in diabetes. |
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