Effects of steroid hormones on age-related expression and modulation of the lysozyme gene of the oviduct of Japanese quail |
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Authors: | Hegde Amita Kanungo M.S. |
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Affiliation: | (1) Biochemistry & Molecular Biology Laboratory, Department of Zoology, Banaras Hindu University, Varanasi, 221005, India |
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Abstract: | The expression of lysozyme gene in the oviduct of Japanese quail is age-dependent. Here we show that the expression of the gene is altered by three steroid hormones: 17 -estradiol (E), progesterone (P) and glucocorticoid (dexamethasone, G), and their combinations E+P, E+G and P+G. We also show that the levels/affinities of trans-acting factors that bind to specific cis-acting elements in the promoter region of the gene change with age and after steroid administration. These factors are sequence-specific, age and steroid-dependent. It is proposed that administration of appropriate doses of steroid hormones after adulthood may extend the reproductive function and egg laying period in birds. |
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Keywords: | cis-acting elements glucocorticoid Japanese quail lysozyme gene progesterone 17 /content/p676713015519234/xxlarge946.gif" alt=" beta" align=" MIDDLE" BORDER=" 0" >-estradiol trans-acting factors |
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