| 自组装短肽在脊髓急性创伤早期减少细胞凋亡的研究 |
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| 引用本文： | 吕斐,王松涛,王婷,刘燕飞,赵晓军. 自组装短肽在脊髓急性创伤早期减少细胞凋亡的研究[J]. 四川动物, 2010, 29(2) |
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| 作者姓名： | 吕斐 王松涛 王婷 刘燕飞 赵晓军 |
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| 作者单位： | 四川大学纳米生物医学技术与膜生物学研究所,成都,610065 |
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| 摘 要： | 目的 为研究在脊髓急性损伤中,自组装短肽溶液对创伤后神经组织的保护作用及创伤后早期神经组织细胞凋亡的时间分布规律.方法 实验使用了手术切断大鼠脊髓胸段T8至T10作为脊髓损伤动物模型,使用末端脱氧核苷酸转移酶介导生物素标记(TUNEL)技术,检测实验后不同时间点的损伤脊髓组织细胞凋亡情况.结果 伤后2 h,损伤区及邻近段开始出现末端标记阳性细胞;伤后8 h,凋亡阳性细胞数达高峰;同时,自组装短肽实验组细胞凋亡较空白对照组少.结论 自组装短肽溶液对急性脊髓创伤组织具有保护作用.
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| 关 键 词： | 自组装短肽 脊髓损伤 细胞凋亡 |
Study on Self-assembled Peptides to Depress Cell Apoptosis in Rat Experimental Acute Spinal Cord Injury |
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| L Fei,WANG Song-tao,WANG Ting,LIU Yan-fei,ZHAO Xiao-jun. Study on Self-assembled Peptides to Depress Cell Apoptosis in Rat Experimental Acute Spinal Cord Injury[J]. Sichuan Journal of Zoology, 2010, 29(2) |
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| Authors: | L Fei WANG Song-tao WANG Ting LIU Yan-fei ZHAO Xiao-jun |
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| Affiliation: | L(U) Fei,WANG Song-tao,WANG Ting,LIU Yan-fei,ZHAO Xiao-jun |
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| Abstract: | Objective To explore self-assembly peptides characteristics to apoptosis following spinal cord injury. Methods Rat model of spinal cord injury was established. Apoptosis in the injured area was examined by using terminal deoxynucleotidyl-mediated nick-end labeling(TUNEL). Results The TUNEL positive cells were detected 2 hours post injury,the number of TUNEL-positive stain reached a maximum 8 hours after injury,and there were fewer TUNEL-positive cells detected in self-assembling peptide group(SAP group). Co... |
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| Keywords: | RADA16-1 self-assembled peptides RADA16-1 spinal cord injury apoptosis |
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