| Combined chemotherapy of platinum and fluorouracil promotes T cell–mediated antitumor immunity |
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| 作者姓名： | Yixiao Luo Siyu Pei Jing Xu Yichuan Xiao Xiaodong Zhu |
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| 作者单位： | Department of Oncology;Department of Medical Oncology;CAS Key Laboratory of Tissue Microenvironment and Tumor |
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| 基金项目： | This work was supported by the grants from the Program of Shanghai Academic/Technology Research Leader(No.20XD1424600);the National Key R&D Program of China(No.2018YFA0902703);the National Natural Science Foundation of China(No.81770567);CAS Key Laboratory of Tissue Microenvironment and Tumor. |
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| 摘 要： | The two-drug combined chemotherapy of platinum and fluorouracil has been reported to efficiently kill tumor cells as the first-line treatment for advanced gastric cancer.However,the effect of these drugs on T cells remains unclear.Here,we showed that T cells including CD4+T cells and CD8+T cells of the patients with advanced gastric cancer after platinum and fluorouracil chemotherapy exhibited enhanced ex vivo proliferation ability as compared to that before chemotherapy.In addition,platinum and fluorouracil also promoted the differentiation of human T cells into Th1 and Th9 subtypes and cytotoxic T lymphocytes(CTLs)in vitro and in vivo.Accordingly,the combination therapy greatly suppressed tumor growth with increased tumor infiltration of Th1,Th9,and CTL cells in a mouse tumor model.Moreover,in activated T cells,long-term treatment with these two drugs further facilitates T cell activation along with promoted nuclear factor-κB(NF-κB)activation.Our findings demonstrate a previously unidentified function of platinum and fluorouracil combination chemotherapy in promoting T cell–mediated antitumor immunity.
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| 关 键 词： | CHEMOTHERAPY antitumor immunity T cell activation NF-κB signaling |
Combined chemotherapy of platinum and fluorouracil promotes T cell-mediated antitumor immunity |
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| Yixiao Luo,Siyu Pei,Jing Xu,Yichuan Xiao,Xiaodong Zhu.Combined chemotherapy of platinum and fluorouracil promotes T cell-mediated antitumor immunity[J].Acta Biochimica et Biophysica Sinica,2021(1):29-35. |
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| Authors: | Yixiao Luo Siyu Pei Jing Xu Yichuan Xiao Xiaodong Zhu |
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| Abstract: | The two-drug combined chemotherapy of platinum and fluorouracil has been reported to efficiently kill tumor cells as the first-line treatment for advanced gastr... |
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