| RNA结合蛋白RBM6的研究进展 |
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| 引用本文： | 荆昕涛,陈妍珂,黄辰.RNA结合蛋白RBM6的研究进展[J].中国细胞生物学学报,2021(2). |
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| 作者姓名： | 荆昕涛 陈妍珂 黄辰 |
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| 作者单位： | 西安交通大学医学部基础医学院细胞生物学与遗传学系;西安交通大学环境与疾病相关基因教育部重点实验室 |
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| 基金项目： | 陕西省国际科技合作与交流计划面上项目(批准号:2017KW-059);陕西省科技资源开放共享平台项目(批准号:2018PT-09)资助的课题。 |
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| 摘 要： | RBM6(RNA binding motif protein 6)是一种RNA结合蛋白,存在5种可变剪接体。以往的研究发现:与正常组织相比,这些剪接体在肺癌和乳腺癌等肿瘤组织中的表达均有显著变化,但其功能尚不清楚。越来越多的研究显示,RBM6可能是肿瘤进展中的一个重要的调控因子。该文将从RBM6的基因与蛋白结构、作用机制以及与疾病的关系三个方面对RBM6的研究进展进行总结。
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| 关 键 词： | RNA结合蛋白 RBM6 肿瘤 可变剪接体 |
Research Progress of RNA Binding Motif Protein RBM6 |
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| Authors: | JING Xintao CHEN Yanke HUANG Chen |
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| Institution: | (Department of Cell Biology and Genetics,Basic Medical School,Xi’an Jiaotong University,Xi’an 710061,China;Key Laboratory of Environment and Genes Related to Diseases,Ministry of Education,Xi’an Jiaotong University,Xi’an 710061,China) |
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| Abstract: | RBM6 is a type of RNA binding protein with five splice variants.Previous researchs have found that compared with the normal tissues,the expression of these splices in tumor tissues,such as lung cancer and breast cancer,has significantly changed.However,their function is still unclear.Besides,more and more studies have shown that RBM6 may be considered as an important regulator in tumor progression.This review summarizes the research progress of RBM6 from three aspects:gene and protein structure,mechanisms,and the relationship with diseases. |
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| Keywords: | RNA binding protein RBM6 tumor splice variants |
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