Bioactive Compounds from Marine Bacteria and Fungi |
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| Authors: | Abdessamad Debbab Amal H Aly Wen H Lin Peter Proksch |
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| Institution: | 1.Institut für Pharmazeutische Biologie und Biotechnologie, Heinrich‐Heine Universitaet Duesseldorf, Germany.;2.National Research Laboratories of Natural and Biomimetic Drugs, Peking University, Health Science Center, 100083 Beijing, People''s Republic of China. |
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| Abstract: | Marine bacteria and fungi are of considerable importance as new promising sources of a huge number of biologically active products. Some of these marine species live in a stressful habitat, under cold, lightless and high pressure conditions. Surprisingly, a large number of species with high diversity survive under such conditions and produce fascinating and structurally complex natural products. Up till now, only a small number of microorganisms have been investigated for bioactive metabolites, yet a huge number of active substances with some of them featuring unique structural skeletons have been isolated. This review covers new biologically active natural products published recently (2007–09) and highlights the chemical potential of marine microorganisms, with focus on bioactive products as well as on their mechanisms of action. |
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