| 稳态及衰老情况下骨髓微环境对造血干细胞的调控作用 |
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| 引用本文： | 张沛雯,马小彤.稳态及衰老情况下骨髓微环境对造血干细胞的调控作用[J].中国细胞生物学学报,2021(2):420-427. |
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| 作者姓名： | 张沛雯 马小彤 |
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| 作者单位： | 中国医学科学院血液病医院（中国医学科学院血液学研究所） |
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| 基金项目： | 国家自然科学基金(批准号:82070113)资助的课题。 |
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| 摘 要： | 稳态下,骨髓微环境(bone marrow microenvironment)被证实能通过多种信号通路和细胞因子调控造血干细胞(hematopoietic stem cells,HSCs)的自我更新、增殖、分化和迁移能力以维持造血系统的稳定.在衰老过程中,HSCs功能受损会导致造血系统功能的退化以及年龄相关的免疫应答的...
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| 关 键 词： | 造血干细胞 骨髓微环境 稳态 衰老 |
Regulation of Bone Marrow Microenvironment on Hematopoietic Stem Cells under Steady State and Aging |
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| Authors: | ZHANG Peiwen MA Xiaotong |
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| Institution: | (State Key Laboratory of Experimental Hematology,National Clinical Research Center for Blood Diseases,Institute of Hematology&Blood Diseases Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin 300020,China) |
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| Abstract: | Bone marrow microenvironment was proved to regulate the self-renewal,proliferation,differentiation and migration of HSCs(hematopoietic stem cells)via different signal pathways and cytokines under steady state.Upon aging,the defective function of HSCs leads to the deterioration of hematopoietic integrity and changes of the age-related immune response,as well as increased susceptibility to anemia,autoimmune and myeloproliferative disorders.HSCs aging was initially thought to be induced by cell-intrinsic dysregulation.However,current studies are revealing that the bone marrow microenvironment not only regulates HSCs function under homeostasis,but also makes contributions to HSCs aging.This review will cover our understanding of HSCs regulation by bone marrow microenvironment under steady state and aging. |
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| Keywords: | hematopoietic stem cells bone marrow microenvironment steady state aging |
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