Proteomics and its applications for biomarker discovery in human saliva |
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Authors: | Hua Xiao David T Wong |
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Institution: | 1.Dental Research Institute.;2.School of Dentistry.;3.Jonsson Comprehensive Cancer Center.;4.Division of Head and Neck Surgery/Otolaryngology.;5.Henry Samueli School of Engineering, University of California, Los Angeles, California 9009. |
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Abstract: | Human saliva is a biological fluid with enormous diagnostic potential. Because saliva can be non-invasively collected, it provides an attractive alternative
for blood, serum or plasma. It has been postulated that the blood concentrations of many components are reflected in saliva. Saliva harbors a wide array of
proteins, which can be informative for the detection of diseases. Profiling the proteins in saliva over the course of disease progression could reveal
potential biomarkers indicative of different stages of diseases, which may be useful in medical diagnostics. With advanced instrumentation and developed
refined analytical techniques, proteomics is widely envisioned as a useful and powerful approach for salivary proteomic biomarker discovery. As
proteomic technologies continue to mature, salivary proteomics have great potential for biomarker research and clinical applications. The progress and
current status of salivary proteomics and its application in the biomarker discovery of oral and systematic diseases will be reviewed. The scientific and
clinical challenges underlying this approach will also be discussed. |
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Keywords: | Saliva Biomarkers Proteomics |
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