| LAG-3的免疫学功能及其抗体药物的研究进展 |
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| 引用本文： | 田宝俊,于红阳,徐明波,曹荣月,杨仲璠. LAG-3的免疫学功能及其抗体药物的研究进展[J]. 中国细胞生物学学报, 2021, 0(2): 484-492 |
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| 作者姓名： | 田宝俊 于红阳 徐明波 曹荣月 杨仲璠 |
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| 作者单位： | 中国药科大学生命科学与技术学院;北京双鹭药业股份有限公司 |
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| 摘 要： | 淋巴细胞活化因子-3(lymphocyte activation gene-3,LAG-3)又名CD223,为一类免疫检查点受体蛋白,主要表达于活化的免疫细胞中.LAG-3分子在生理条件下可维持机体免疫稳态,在肿瘤微环境中可介导肿瘤细胞的免疫逃逸,因此,可将LAG-3作为肿瘤免疫治疗的新靶点进行研究.LAG-3阻断性抗...
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| 关 键 词： | LAG-3 免疫逃逸 LAG-3抗体 肿瘤免疫治疗 抗体药物联用 |
Advances in the Research of the Immunological Function of LAG-3 and Its Antibody Drugs |
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| TIAN Baojun,YU Hongyang,XU Mingbo,CAO Rongyue,YANG Zhong. Advances in the Research of the Immunological Function of LAG-3 and Its Antibody Drugs[J]. Chinese Journal of Cell Biology, 2021, 0(2): 484-492 |
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| Authors: | TIAN Baojun YU Hongyang XU Mingbo CAO Rongyue YANG Zhong |
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| Affiliation: | (School of Life Science and Technology,China Pharmaceutical University,Nanjing 210009,China;Beijing Shuanglu Pharmaceutical Co.,Ltd.,Beijing Engineering Research Center for Recombinant Proteins and Long-Acting Preparations,Beijing 100143,China) |
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| Abstract: | LAG-3(lymphocyte activation gene-3),also known as CD223,is a type of immune checkpoint receptor protein,which is primarily expressed in activated immune cells.LAG-3 can maintain immune homeostasis under physiological conditions and mediate the immune escape of tumor cells in the TME(tumor microenvironment).Therefore,LAG-3 can be used as a new target for tumor immunotherapy.LAG-3 blocking antibody can effectively relieve the tolerance caused by other immune checkpoint inhibitors,and has a better clinical effect in drug combination.At present,many LAG-3-related antibody drugs are in the development stage,some of which have entered the clinical stage.This paper systematically reviews the structure,expression,and function of LAG-3,as well as elaborates the clinical research progress and market situation of LAG-3-related antibody drugs. |
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| Keywords: | LAG-3 immune escape LAG-3 antibody tumor immunotherapy antibody-drug combination |
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