Inhibition of the rat adrenal ornithine decarboxylase activity by immobilization stress and/or dexamethasone |
| |
Authors: | Karam F.A. Soliman R.Renee Reams Matty O. Udoye Vani K. Nonavinakere |
| |
Affiliation: | Florida A&M University College of Pharmacy and Pharmaceutical Sciences, Tallahassee, FL 32307, USA |
| |
Abstract: | The effects of immobilization stress and/or dexamethasone (DEX) on the adrenal ornithine decarboxylase (ODC) activities of sham-operated and adrenal-medulloectomized (enucleated) male Sprague-Dawley rats were investigated. On day 11 after surgery, rats were injected with saline or DEX (1 mg/kg), 3 h before the time of sacrifice (0600 h or 1800 h). Four groups, from sham-operated and enucleated rats (ENU) treated with saline or DEX were subjected to immobilization stress for 1 h prior to sacrifice. Groups of rats from stress-sham-DEX, non stress-sham-DEX, stress-sham, non stress-sham, stress-ENU-DEX, non stress-ENU-DEX, stress-ENU, and non stress-ENU were sacrificed at 0600 h or 1800 h on day 11 after surgery. Adrenal glands were excised and later analyzed for ODC activities. Results indicated that DEX and/or immobilization stress inhibited ODC activities (p < 0.05) in normal and regenerating adrenal glands at 1800 h and ODC activity varies diurnally, the activity being greater at 1800 h than at 0600 hours (p < 0.001). |
| |
Keywords: | ornithine decarboxylase activity stress dexamethasone adrenal gland |
本文献已被 ScienceDirect 等数据库收录! |
|