A microdialysis study of the effects of the nicotinic agonist RJR-2403 on cortical release of acetylcholine and biogenic amines |
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Authors: | Kathleen L. Summers Dr. Patrick Lippiello Ezio Giacobini |
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Affiliation: | (1) Department of Pharmacology, Southern Illinois University School of Medicine, 62794-1222 Springfield, Illinois;(2) Research & Development department, R. J. Reynolds Tobacco Company, BGTC Bldg. 611-13/CO, 27102 Winston-Salem, North Carolina |
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Abstract: | Transcortical dialysis was employed to investigate the effects of subcutaneous (s.c.) injections of RJR-2403 (1.2–7.2 μmol/kg) on extracellular levels of acetylcholine (ACh), norepinephrine (NE), dopamine (DA), and serotonin (5-HT) in rat. Systemic administration of RJR-2403 produced a 90% increase of cortical extracellular ACh levels that persisted for up to 90 minutes after injection. Norepinephrine and DA release were increased 124% and 131% above basal values, respectively. Serotonin (5-HT) levels in the dialysate were also significantly elevated by RJR-2403 (3.6 μmol/kg, s.c.) 70% above baseline at 90 minutes post-injection. Comparison of these responses to those of (−)nicotine from a previous study reveals little difference between the two compounds in their ability to influence cortical neurotransmitter release following systemic administration. |
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Keywords: | RJR-2403 nicotine neurotransmitters cortex microdialysis |
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