Correlation Between Iodine Intake and Thyroid Function in Subjects with Normal Thyroid Function |
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Authors: | Sena Hwang Eun Young Lee Woo Kyung Lee Dong Yeob Shin Eun Jig Lee |
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Institution: | (1) Endocrinology, Severance Hospital Integrative Research Institute for Cerebral and Cardiovascular Diseases, Department of Internal Medicine, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, 120-752, South Korea; |
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Abstract: | Excessive iodine intake is known to induce hypothyroidism in people who have underlying thyroid disorders. However, few studies
have been performed on subjects with normal thyroid function without a history of autoimmune thyroid disease. We hypothesized
that high iodine intake may cause a subtle change in thyroid function even in subjects with normal thyroid function. We analyzed
337 subjects (64 men and 273 women; mean age, 49 years) who showed normal levels of thyroid peroxidase antibodies (TPO-Ab)
and thyroglobulin antibodies (Tg-Ab) by measuring the urinary iodine excretion, free T4 (FT4), and thyroid-stimulating hormone
(TSH). The results showed urinary iodine excretion had negative correlation with FT4 (γ = −0.11, p = 0.043) and showed a positive trend with TSH (γ = 0.10, p = 0.068). We found that 61.7% of subjects had circulating TPO-Ab within normal reference range. In all subjects, TPO-Ab levels
were negatively correlated with FT4 (γ = −0.17, p = 0.002) and positively with TSH (γ = 0.13, p = 0.021). In conclusion, high iodine intake can negatively affect thyroid hormone levels in subjects with normal thyroid
function. Population-based study will be helpful for further clarification. |
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