Influence of sCD40L on gastric cancer cell lines |
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| Authors: | Rui Li Wei-Chang Chen Xue-Qin Pang Wen-Yan Tian Xue-Guang Zhang |
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| Institution: | (1) Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Key Laboratory of Medicine and Clinical Immunology of Jiangsu Province, Suzhou, 215006, China;(2) Institute of Medical Biotechnology, Soochow University, Suzhou, 215007, China; |
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| Abstract: | The CD40 signaling pathway plays a key role in tumor cell proliferation, differentiation, and apoptosis. Gastric cancer usually
possesses a higher level of CD40 expression than normal tissue. We evaluated inhibition of soluble CD40 ligand (sCD40L) in
apoptosis induction of gastric cancer cells. Gastric cancer cells (AGS and BGC-823) were incubated with sCD40L. Cell viability
and cell cycle were determined by methyl-tetrazolium (MTT) assay and flow cytometry, respectively. The results showed that
sCD40L hindered cell growth, arrested cells at G0/G1 phase and induced apoptosis. In conclusion, sCD40L suppress growth of
gastric cancer cells through apoptosis induction and cell cycle quiescence. This work will provided a new approach to gene
therapy of gastric cancer. |
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