Heterogeneity in human soluble guanylate cyclase due to alternative splicing. |
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| Authors: | V Chhajlani P A Fr?ndberg J Ahlner K L Axelsson J E Wikberg |
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| Affiliation: | Department of Pharmacology, Ume? University, Sweden. |
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| Abstract: | Two forms of the smaller subunit of the human soluble guanylate cyclase enzyme have been cloned by using PCR. One of the clones (HSGC-1) is identical to bovine and rat lung smaller subunit cyclase. However, the other (HSGC-2) is lacking 33 amino acids. Comparison of its sequence with published partial genomic sequences of bovine guanylate cyclase indicates that HSGC-2 is formed due to alternative splicing. |
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